Which Statin Is Safest In Liver Disease?

What is the safest statin for liver disease?

Large randomized studies have demonstrated the safety of low to moderate doses of lovastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin and have not shown a significant increase in the risk of biochemical liver disorders.

Which statin is best for treating liver disease?

Statin therapy such as atorvastatin (Lipitor), Crestor (rosuvastatin), or simvastatin (Zocor) has been shown to be safe in patients with NAFLD. This is important: even if liver function tests are abnormal due to fatty liver changes, you can still take statins, and the drugs can often reduce obesity.

Which statin is the least harmful to the liver?

Statin subclasses and their pleiotropic effects

While atorvastatin, lovastatin, simvastatin, and fluvastatin are lipophilic and metabolized by the cytochrome P450 system, pravastatin and pitavastatin are hydrophilic and undergo minimal hepatic metabolism, while rosuvastatin exhibits intermediate behavior [10]. .

Which statin is more effective for the liver?

Low-dose statins such as atorvastatin (Lipitor) are safe for people with mild liver disease (such as fatty liver and mild liver test abnormalities such as ALT and AST).

What is the best statin for liver cirrhosis?

Table 2

Drug Affected statins (risk assessment)
Telaprevir Atorvastatin (X), fluvastatin (C), lovastatin (X), pitavastatin (C), pravastatin (C), rosuvastatin (C), simvastatin (X)
Norfloxacin atorvastatin (C), lovastatin (C), simvastatin (C)
Rifaximin Atorvastatin (C)
Spironolactone Atorvastatin (C)

Can statins be taken for liver disease?

However, recent data and a Liver Panel safety review of statins suggest that statins are generally well tolerated in patients with chronic liver disease such as NAFLD, primary biliary cirrhosis, and hepatitis C virus.

Can you take statins for liver cirrhosis?

27 In patients with chronic liver disease and compensated cirrhosis, statins are safe and effective and should not be avoided for reasons of hepatotoxicity. Statin use is not indicated and should be discontinued in acute hepatitis and decompensated cirrhosis.

Which statin is the least harmful to the liver?

Based on data from the Swedish National Registry, the results show that people who took lipophilic statins (in this case, atorvastatin or simvastatin) had a significantly lower risk of developing liver cancer than those who did not take them (3.3% vs. ,one %). . %).