- A leading strand is the strand synthesized in the 5 3 direction while a lagging strand is the strand synthesized in the 3 5 direction 2. The leading strand is synthesized continuously while a lagging strand synthesizes into fragments called Okazaki becomes fragments.
What is the difference between leading strand and lagging strand in DNA replication?
DNA synthesis takes place continuously on the leading strand. On the lagging strand, DNA synthesis is restarted multiple times as the helix unwinds, resulting in many short fragments called “Okazaki fragments”. DNA ligase joins the Okazaki fragments into a single DNA molecule.
What is the difference between the mainstream and delayed stream quizlets?
The leading strand is correctly aligned so that DNA polymerase III adds nucleotides in the 5 3 direction to the replication fork in one continuous strand, while the lagging strand extends in the opposite direction (3 5) and must be replicated backwards, away from replication Fork.